| 2020 Jan 12;21(2):482. doi: 10.3390/ijms21020482. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Cota-Coronado A, Durnall JC, Díaz NF, Thompson LH, Díaz-Martínez NE. Remarkably, the widely expressed RNA binding proteins Srsf11 and Rnps1 directly, preferentially, and frequently co-activate these microexons. 2020 Aug 1;34(15-16):1005-1016. doi: 10.1101/gad.338962.120. -. Nat Genet 2000; 24: 343–345. NIH The CRISPR/Cas9 system. Genes Dev. COVID-19 is an emerging, rapidly evolving situation. Although the spontaneous excitatory postsynaptic currents (sEPSCs) did not change significantly, when the frequencies of both sIPSCs and sEPSCs were further analyzed, we found the whole postsynaptic activity transferred from the inhibition-dominated state to excitation in patient-derived neuronal networks, suggesting that changes in sIPSCs alone were sufficient to significantly reverse the excitatory level of spontaneous postsynaptic activity. 2020 Apr;57(4):2085-2100. doi: 10.1007/s12035-019-01861-w. Epub 2020 Jan 11. Dev Med Child Neurol 2011; 53: 1–6. The advent of the CRISPR/Cas9 system of gene disruption has ushered in a new era of genetic investigation. | 2007;65:363–71. Blazquez L, Emmett W, Faraway R, Pineda JMB, Bajew S, Gohr A, Haberman N, Sibley CR, Bradley RK, Irimia M, Ule J. Mol Cell. -, Escayg A, MacDonald BT, Meisler MH, Baulac S, Huberfeld G, An-Gourfinkel I et al. NIH | The two alterations in Nav further reduced the amplitudes and enhanced the thresholds of action potential in patient-derived GABAergic neurons, and led to weakened spontaneous inhibitory postsynaptic currents (sIPSCs) in the patient-derived neuronal network. HHS Hedrich UB, Liautard C, Kirschenbaum D, Pofahl M, Lavigne J, Liu Y, Theiss S, Slotta J, Escayg A, Dihné M, Beck H, Mantegazza M, Lerche H. J Neurosci. 2020 May 12;14:104. doi: 10.3389/fncel.2020.00104. Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJ. eCollection 2017. Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism. Repurposing CRISPR/Cas9 for in situ functional assays. Comput Struct Biotechnol J. Xiao-Jie L, Hui-Ying X, Zun-Ping K, Jin-Lian C, Li-Juan J. J Med Genet. Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, Sharma E, Quesnel-Vallières M, Permanyer J, Maier S, Georgiou J, Irimia M, Sonenberg N, Forman-Kay JD, Gingras AC, Collingridge GL, Woodin MA, Cordes SP, Blencowe BJ. Schutte SS, Schutte RJ, Barragan EV, O'Dowd DK. We found that the mutation c.A5768G, which led to no current of Nav1.1 in exogenously transfected system, influenced the properties of not only Nav current amount, but also Nav activation in Nav1.1-expressing GABAergic neurons. 2020 Oct;50(10):3525-3530. doi: 10.1007/s10803-020-04419-1. Please enable it to take advantage of the complete set of features! These factors form critical interactions with the neuronal splicing regulator Srrm4 and a bi-partite intronic splicing enhancer element to promote spliceosome formation. Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome. Now, it is possible to generate gene-disrupted mouse models in very little time and at very little cost. 1: Figure S1. Approximately 200 genes associated with functionally diverse regulatory layers and enriched in genetic links to autism control neuronal microexons. However, because of the time and cost involved, this technology was not a viable method except in specialist laboratories. ( a )…, Generation of GAD67-tdTomato knock-in human…, Generation of GAD67-tdTomato knock-in human iPSC lines. Trends Biochem Sci. Genes Dev. doi: 10.1093/hmg/ddu125. ( a ) The CRISPR sequence and the associated Cas9…, Conventional versus CRISPR/Cas9 method of…, Conventional versus CRISPR/Cas9 method of gene-disruption. However, because of the time and cost involved, this technology was not a viable method except in specialist laboratories. Hum Mol Genet. Mouse models in male fertility research. Genes Dev. Biosci Rep. 2020 Sep 30;40(9):BSR20201084. | This site needs JavaScript to work properly. Get the latest research from NIH: https://www.nih.gov/coronavirus. CRISPR/Cas: a potential gene-editing tool in the nervous system. 2014 Dec 18;159(7):1511-23. doi: 10.1016/j.cell.2014.11.035. Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development. -, Blume-Jensen P, Jiang G, Hyman R, Lee KF, O’Gorman S, et al. Finally, the mechanisms that direct NPCs to predominantly regenerate the specific neurons lost to damage are unclear. This Highlight article discusses the application of this technology to study the genetics of male fertility and looks at some of the future uses of this system that could be used to reveal the essential and nonessential genetic components of male reproductive mechanisms. -, Roy A, Matzuk MM. (. Emerging Roles of Activity-Dependent Alternative Splicing in Homeostatic Plasticity. Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+. HHS Nat Genet. 2014 Sep 15;23(R1):R40-6. Soc Reprod Fertil Suppl. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, Conventional versus CRISPR/Cas9 method of gene-disruption.
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