Puiman PJ, Burger-Van Paassen N, Schaart MW, De Bruijn AC, De Krijger RR, Tibboel D, Van Goudoever JB, Renes IB: Paneth cell hyperplasia and metaplasia in necrotizing enterocolitis. Paneth cell hyperplasia and metaplasia may be a local response to inflammatory changes in IBD, or a reaction to pan-colonic changes such as altered bacterial flora [11]. Bacterial growth inhibition was analyzed by calculating the number of CFUs in comparison with untreated bacteria. BMC Gastroenterol 14, 93 (2014). Moreover, both preterm CO-R and NEC-R tissue showed higher numbers of Paneth cells compared with term CO. Features: and I.B.R.). This method was similar to that employed by Kelly et al. Escherichia coli (E. coli), Lactococcus lactis (L. lactis), and Lactobacillus rhamnosus (LGG) were grown overnight in LB medium, GM17 medium, and MRS medium (BD, Franklin Lakes, NJ), respectively, at 37°C. 2011, 69: 217-223. Symonds DA: Paneth cell metaplasia in diseases of the colon and rectum. Pathologists describe this group of changes as chronic colitis. This report was presented at the 65th Annual Meeting of the Japanese Pathological Society in. 10.1007/BF00518730. Erlandsen SL, Parsons JA, Taylor TD: Ultrastructural immunocytochemical localization of lysozyme in the Paneth cells of man. https://doi.org/10.1203/PDR.0b013e3182092a9a, DOI: https://doi.org/10.1203/PDR.0b013e3182092a9a, Frontiers in Physiology (A) Antimicrobial activity of protein isolates from ileostomy outflow fluid samples (n = 12) on E. coli, LGG, and L. lactis. 755. Ann Surg 241: 984–989; discussion 989–994. Oxford University Press is a department of the University of Oxford. PCH was present in 8 (67%) of 12 patients with ileo-colonic anastomoses. More than ten Paneth cells per ten crypts at any site was seen only in IBD. Paneth cell-like neuroendocrine metaplasia of benign and cancerous prostate was described in 1992 by Weaver et al. In reanastomosis samples, no differences in Paneth cell abundance between NEC-R and preterm CO-R were observed (Fig. It is possible that altered bowel habit or other physiological changes affected Paneth cell numbers in the control group, so these findings are not necessarily applicable to asymptomatic children. Analyses were performed using GraphPad Prism version 5.0 (GraphPad Software, San Diego, CA). Microscopic. PCM in the context of colorectal adenomas may be associated with a higher risk of colorectal neoplasia. We identified 94 patients with at least 1 TI biopsy diagnosed as acute ileitis (AI) or chronic active ileitis (CAI) within a 5-year period (2005-2010). Peneth Cell Metaplasia in Ulcerative Colitis. The presence/absence of PCH and PGM was identified and the distribution of Paneth cells within the ileal crypts, and Paneth cell degranulation were noted. Paneth cells derive from fast-cycling crypt base columnar cells, which are involved in crypt regeneration; they differentiate whilst migrating towards the crypt base, from which they are eventually cleared by phagocytosis [9, 10]. Paneth cells showed the ultrastructure of serozymogenic cells and secreted their secretory granules by merocrine process. View the article PDF and any associated supplements and figures for a period of 48 hours. https://doi.org/10.1186/1471-230X-14-93, DOI: https://doi.org/10.1186/1471-230X-14-93. Paneth cell metaplasia (PCM) is well described in adults but little is known about the distribution of colonic Paneth cells and the occurrence of PCM in a paediatric population. FEBS Lett. Metaplasia can occur through restitution or regeneration of tissue after intestinal mucosal surface loss, either because of resection and inflammation or both (36).

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